Frontolimbic structural changes in borderline personality disorder

Frontolimbic structural changes in borderline personality disorder.

OBJECTIVE Frontolimbic dysfunction is observed in borderline personality disorder (BPD), with responses to emotional stimuli that are exaggerated in the amygdala and impaired in the anterior cingulate cortex (ACC). This pattern of altered function is consistent with animal models of stress responses and depression, where hypertrophic changes in the amygdala and atrophic changes in the ACC are o...

Early sea changes in borderline personality disorder.

Failure of frontolimbic inhibitory function in the context of negative emotion in borderline personality disorder.

OBJECTIVE The authors sought to test the hypothesis that in patients with borderline personality disorder, the ventromedial prefrontal cortex and associated regions would not be activated during a task requiring motor inhibition in the setting of negative emotion. Such a finding would provide a plausible neural basis for the difficulty borderline patients have in modulating their behavior durin...

Structural brain abnormalities and suicidal behavior in borderline personality disorder.

BACKGROUND Structural brain abnormalities have been demonstrated in subjects with BPD in prefrontal and fronto-limbic regions involved in the regulation of emotion and impulsive behavior, executive cognitive function and episodic memory. Impairment in these cognitive functions is associated with increased vulnerability to suicidal behavior. We compared BPD suicide attempters and non-attempters,...

Personality Dimensions of Temperament and Character in Patients with Borderline Personality Disorder and Bipolar Disorder II

Introduction: The purpose of this study was to investigate and compare personality dimensions of temperament and character in patients with borderline personality and bipolar II disorders in order to evaluate the hypothesis of “belonging of borderline personality disorder in moods disturbance spectrum.” Materials and Methods: 43 patients with borderline personality disorder, 47 patients with bi...